Harnessing the Body’s Innate Ability to Halt Bleeding and Heal
Life-threatening hemorrhage
- The vast majority of deaths from hemorrhage are preventable.
- Seventy percent of all preventable deaths are associated with bleeding at non-compressible areas of the body, where tourniquets, gauzes and topicals are ineffective.
- Up to 90% of preventable deaths from hemorrhage are due to delayed hemostatic control, in which every second is urgent. Once major hemorrhage has started and more blood is lost, there are fewer clotting factors and stopping the flow gets progressively more difficult.
- To date, efforts to develop systemic therapies for noncompressible major hemorrhage have been limited by safety issues, creating unacceptable risk of off-target clotting in healthy tissues.
References: Cannon 2018, Eastridge et al 2019, Gimbel et al 2018, Kelly et al 2008, ClinCalc Drug Usage Statistics 2020
Bleeding disorders
- More than 20 million people live with inherited blood or bleeding disorders.
- Despite tremendous progress for patients with hemophilia, some patients are not candidates for new therapies, are at risk for inhibitor development for mainstay factor-based therapies, and struggle with standard approaches.
- Many rare bleeding disorders lack approved treatments.
- Therefore novel, effective mechanisms of action are urgently needed.
References: www.pathwaytocures.org, Okaygoun et al 2021
Biomimetic Solutions for Hemorrhage Control
References: Cannon 2019; Kelly et al 2008, Brohi et al 2019, Eastridge et al 2019, Clark et al 2002