Cayuga Biotech

Management of Bleeding

Excessive bleeding is a global threat which can affect all populations, but is especially critical for patients on anticoagulant therapy or those who have a rare bleeding disorder. Across all sources of bleeding, the probability of death increases 1 % for every 3 minutes of uncontrolled hemorrhage, meaning that rapid intervention is critical to survival.

CAY001 is a first-in-class drug which aims to accelerate the body's natural clotting response even in patients with compromised platelet function. Unlike natural platelets, CAY001 is can be mass-manufactured, is stable at room temperature, and does not require type matching, allowing it to be deployed with first responders.

Harnessing Polyphosphate

Small chain polyphosphate (polyP) is released from platelets upon injury. This natural polymer is rapidly metabolized within in-vivo models and has been show to accelerate clot formation within in-vitro models. Cayuga Biotech is developing a novel formulation of polyP (CAY001) with the aim of improving the in-vivo stability and potency of polyP in accelerating thrombin production and clot formation at injury sites without inducing unwanted clotting.

Key Publications

Kudela D. “Restoring Hemostasis Following Injury Using Polyphosphate-Coated Silica Nanoparticles.” The Federation of American Societies for Experimental Biology Journal. 2017, 31, 978.13.

Kudela D., Smith S.A., May-Masnou A., Braun, G.B., Pallaoro, A., Nguyen, C.K., Chuong, T.T., Nownes, S., Allen, R., Parker, N.R., Rashidi, H.H., Morrissey, J.H., Stucky, G.D. “Clotting Activity of Polyphosphate-Functionalized Silica Nanoparticles.” Angewandte Chemie International Edition. 2015, 54, 4018-4022.

Smith S.A., Choi S.H., Davis-Harrison R., Huyck J., Boettcher J., Rienstra C.M., Morrissey J.H. “Polyphosphate exerts differential effects on blood clotting, depending on polymer size.” Blood. 2010, 116, 4353-4359.

Smith S.A., Morrissey J.H. “Polyphosphate as a general procoagulant agent.” Journal of Thrombosis and Haemosasis. 2008, 6, 1750-1756.