Our mission is to harness biomimetic polyphosphate to address pressing unmet needs in human health. Polyphosphate plays several roles in human biology. Our initial focus for drug development leverages polyphosphate’s role in hemostasis.
Bleeding: Every year nearly 2 million people die of hemorrhage
Wound healing: Non-healing wounds and severe burns affect nearly 6 million people in the US each year
Lead candidate, CAY001, is anticipated to enter the clinic in 2022 for major bleeding in patients treated with anti-platelet medications. CAY001 is in development for additional follow-on indications including anti-coagulant related bleeding, refractory GI bleeding and trauma. In preclinical studies CAY001 has been shown to accelerate hemostasis without off-target thromboembolism.
Polyphosphate activity is dictated by the chain length of the molecule. With a core capability in materials science, Cayuga optimizes biomimetic nanoparticle formulations of varying polyphosphate lengths for unique applications, including serious bleeding, rare bleeding disorders, central nervous system bleeding and wound healing.
Kudela D. “Restoring Hemostasis Following Injury Using Polyphosphate-Coated Silica Nanoparticles.” The Federation of American Societies for Experimental Biology Journal. 2017, 31, 978.13.
Kudela D., Smith S.A., May-Masnou A., Braun, G.B., Pallaoro, A., Nguyen, C.K., Chuong, T.T., Nownes, S., Allen, R., Parker, N.R., Rashidi, H.H., Morrissey, J.H., Stucky, G.D. “Clotting Activity of Polyphosphate-Functionalized Silica Nanoparticles.” Angewandte Chemie International Edition. 2015, 54, 4018-4022.
Smith S.A., Choi S.H., Davis-Harrison R., Huyck J., Boettcher J., Rienstra C.M., Morrissey J.H. “Polyphosphate exerts differential effects on blood clotting, depending on polymer size.” Blood. 2010, 116, 4353-4359.
Smith S.A., Morrissey J.H. “Polyphosphate as a general procoagulant agent.” Journal of Thrombosis and Haemosasis. 2008, 6, 1750-1756.
Massachusetts
General Hospital,
Harvard
Medical School,
Department
of Emergency Medicine
Professor of Anesthesiology,
Critical Care, and Surgery
Duke
University,
Polyphosphate
expert
Biological
Chemistry Department,
University
of Michigan Medical School
National Academy of Science
Materials Department, UCSB
Cayuga to present at DeepTechU venture conference on May 5, 2022
https://www.deeptechu.com/
Cayuga Biotech announces Andrea Ashford-Hicks as new CEO
https://www.businesswire.com/news/home/20220303005697/en/Cayuga-Biotech-Appoints-Andrea-Ashford-Hicks-as-Chief-Executive-Officer
Cayuga selected for DOD's Joint Warfighter Medical Research Program
Cayuga will present at IndieBio Demo Day:
https://www.eventbrite.com/e/indiebio-demo-day-2020-october-27th-28th-tickets-119166613549
Cayuga Biotech wins UC Startup Competition and is named a
finalist for the Extreme Tech Challenge in June
https://engineering.ucsb.edu/news/materials-alum-wins-uc-startup-showcase-advances-global-competition
Cayuga Biotech named a finalist for the Army xTechSearch 3.0
https://www.arl.army.mil/xtechsearch/competition.html#xtech3
Cayuga is proud to be a member of the IndieBio Accelerator program. In addition, we are collaborating with DARPA as well as the United States Army.