Cayuga Biotech

Harnessing Polyphosphate to Treat Serious Bleeding

Cayuga's Mission

Serious bleeding is a major cause of morbidity and mortality worldwide and outcomes are linked to how quickly hemostasis can be achieved. Cayuga Biotech's mission is to harness the potential of polyphosphate to address uncontrolled bleeding episodes. Our first in class drug, CAY001, is in preclinical development and has been designed to accelerate control of bleeding across multiple underlying causes, including:

  • Antiplatelet-induced bleeding

  • Anticoagulant-induced bleeding

  • Traumatic hemorrhage

  • Platelet dysfunction and orphan bleeding disorders


Science & Technology

Management of Bleeding

Excessive bleeding is a global threat which can affect all populations, but is especially critical for patients on anticoagulant therapy or those who have a rare bleeding disorder. Across all sources of bleeding, the probability of death increases 1 % for every 3 minutes of uncontrolled hemorrhage, meaning that rapid intervention is critical to survival.

CAY001 is a first-in-class drug which aims to accelerate the body's natural clotting response even in patients with compromised platelet function. Unlike natural platelets, CAY001 is can be mass-manufactured, is stable at room temperature, and does not require type matching, allowing it to be deployed with first responders.

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Harnessing Polyphosphate

Small chain polyphosphate (polyP) is released from platelets upon injury. This natural polymer is rapidly metabolized within in-vivo models and has been show to accelerate clot formation within in-vitro models. Cayuga Biotech is developing a novel formulation of polyP (CAY001) with the aim of improving the in-vivo stability and potency of polyP in accelerating thrombin production and clot formation at injury sites without inducing unwanted clotting.

Key Publications

Kudela D. “Restoring Hemostasis Following Injury Using Polyphosphate-Coated Silica Nanoparticles.” The Federation of American Societies for Experimental Biology Journal. 2017, 31, 978.13.

Kudela D., Smith S.A., May-Masnou A., Braun, G.B., Pallaoro, A., Nguyen, C.K., Chuong, T.T., Nownes, S., Allen, R., Parker, N.R., Rashidi, H.H., Morrissey, J.H., Stucky, G.D. “Clotting Activity of Polyphosphate-Functionalized Silica Nanoparticles.” Angewandte Chemie International Edition. 2015, 54, 4018-4022.

Smith S.A., Choi S.H., Davis-Harrison R., Huyck J., Boettcher J., Rienstra C.M., Morrissey J.H. “Polyphosphate exerts differential effects on blood clotting, depending on polymer size.” Blood. 2010, 116, 4353-4359.

Smith S.A., Morrissey J.H. “Polyphosphate as a general procoagulant agent.” Journal of Thrombosis and Haemosasis. 2008, 6, 1750-1756.

Cayuga Biotech Team

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Damien Kudela, PhD
Co-founder
Inventor NanopolyP


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Kyle Ploense, PhD
Co-founder



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Nathan Ogden, PhD
Senior Scientist



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Andrea Ashford-Hicks
Senior Advisor

 


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David McGuinn, PhD, DABT
Regulatory Advisor

Toxicology expert
23 years FDA experience


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Mark Tracy, PhD
CMC Advisor

President, Tracy BioConsulting


Medical Advisors

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Josh Goldstein, MD, PhD
Medical Advisor

Massachusetts General Hospital,
Harvard Medical School,
Department of Emergency Medicine


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Jerrold Levy, MD
Medical Advisor

Professor of Anesthesiology,
Critical Care, and Surgery

Duke University,


Business Advisors

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Karen Boezi
Business Advisor

Former CEO Redwood Bioscience (CTLT)
Partner, Thomas, McNerney & Partners


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Ajay Rai
Business Advisor

VP Business Development,
Frequency Therapeutics


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Nancy Stagliano, PhD
Business Advisor

CEO Neuron23 Inc.,
Former CEO True North Therapeutics, iPierian, CytomX



Scientific Advisors

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Prof. James Morrissey
Scientific Advisor

Polyphosphate expert
Biological Chemistry Department,
University of Michigan Medical School


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Prof. Galen Stucky
Scientific Advisor

National Academy of Science
Materials Department, UCSB


News

News and Events:

Cayuga selected for DOD's Joint Warfighter Medical Research Program

Cayuga will present at IndieBio Demo Day:
https://www.eventbrite.com/e/indiebio-demo-day-2020-october-27th-28th-tickets-119166613549

Cayuga Biotech wins UC Startup Competition and is named a finalist for the Extreme Tech Challenge in June
https://engineering.ucsb.edu/news/materials-alum-wins-uc-startup-showcase-advances-global-competition

Cayuga Biotech named a finalist for the Army xTechSearch 3.0
https://www.arl.army.mil/xtechsearch/competition.html#xtech3

Our Funding:

Cayuga is proud to be a member of the IndieBio Accelerator program. In addition, we are collaborating with DARPA as well as the United States Army.


IndieBio

DARPA

Media