Cayuga Biotech

Harnessing biomimetic polyphosphate
for human health

Cayuga's Mission

Our mission is to harness biomimetic polyphosphate to address pressing unmet needs in human health. Polyphosphate plays several roles in human biology. Our initial focus for drug development leverages polyphosphate’s role in hemostasis.

  • Bleeding: Every year nearly 2 million people die of hemorrhage

  • Wound healing: Non-healing wounds and severe burns affect nearly 6 million people in the US each year


Lead candidate, CAY001, is anticipated to enter the clinic in 2022 for major bleeding in patients treated with anti-platelet medications. CAY001 is in development for additional follow-on indications including anti-coagulant related bleeding, refractory GI bleeding and trauma. In preclinical studies CAY001 has been shown to accelerate hemostasis without off-target thromboembolism.


Science & Technology

Polyphosphate activity is dictated by the chain length of the molecule. With a core capability in materials science, Cayuga optimizes biomimetic nanoparticle formulations of varying polyphosphate lengths for unique applications, including serious bleeding, rare bleeding disorders, central nervous system bleeding and wound healing.

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Key Publications

Kudela D. “Restoring Hemostasis Following Injury Using Polyphosphate-Coated Silica Nanoparticles.” The Federation of American Societies for Experimental Biology Journal. 2017, 31, 978.13.

Kudela D., Smith S.A., May-Masnou A., Braun, G.B., Pallaoro, A., Nguyen, C.K., Chuong, T.T., Nownes, S., Allen, R., Parker, N.R., Rashidi, H.H., Morrissey, J.H., Stucky, G.D. “Clotting Activity of Polyphosphate-Functionalized Silica Nanoparticles.” Angewandte Chemie International Edition. 2015, 54, 4018-4022.

Smith S.A., Choi S.H., Davis-Harrison R., Huyck J., Boettcher J., Rienstra C.M., Morrissey J.H. “Polyphosphate exerts differential effects on blood clotting, depending on polymer size.” Blood. 2010, 116, 4353-4359.

Smith S.A., Morrissey J.H. “Polyphosphate as a general procoagulant agent.” Journal of Thrombosis and Haemosasis. 2008, 6, 1750-1756.

Pipeline

Cayuga Biotech Team

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Andrea Ashford-Hicks
CEO

 


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Damien Kudela, PhD
Co-founder, CSO
Inventor CAY001


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Kyle Ploense, PhD
Co-founder
Head of Research



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Nathan Ogden, PhD
Senior Scientist



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David McGuinn, PhD, DABT
Regulatory Advisor


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Mark Tracy, PhD
CMC Advisor


Medical Advisors

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Josh Goldstein, MD, PhD
Medical Advisor

Massachusetts General Hospital,
Harvard Medical School,
Department of Emergency Medicine


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Jerrold Levy, MD
Medical Advisor

Professor of Anesthesiology,
Critical Care, and Surgery

Duke University,


Business Advisors

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Karen Boezi
Business Advisor


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Ajay Rai
Business Advisor



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Nancy Stagliano, PhD
Business Advisor




Scientific Advisors

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Prof. James Morrissey
Scientific Advisor

Polyphosphate expert
Biological Chemistry Department,
University of Michigan Medical School


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Prof. Galen Stucky
Scientific Advisor

National Academy of Science
Materials Department, UCSB


News

News and Events:

Cayuga to present at DeepTechU venture conference on May 5, 2022
https://www.deeptechu.com/

Cayuga Biotech announces Andrea Ashford-Hicks as new CEO
https://www.businesswire.com/news/home/20220303005697/en/Cayuga-Biotech-Appoints-Andrea-Ashford-Hicks-as-Chief-Executive-Officer

Cayuga selected for DOD's Joint Warfighter Medical Research Program

Cayuga will present at IndieBio Demo Day:
https://www.eventbrite.com/e/indiebio-demo-day-2020-october-27th-28th-tickets-119166613549

Cayuga Biotech wins UC Startup Competition and is named a finalist for the Extreme Tech Challenge in June
https://engineering.ucsb.edu/news/materials-alum-wins-uc-startup-showcase-advances-global-competition

Cayuga Biotech named a finalist for the Army xTechSearch 3.0
https://www.arl.army.mil/xtechsearch/competition.html#xtech3

Our Funding:

Cayuga is proud to be a member of the IndieBio Accelerator program. In addition, we are collaborating with DARPA as well as the United States Army.


IndieBio

DARPA

Media