Our Pipeline
- First-in-class, CAY001, is an optimized polyP-SNP complex is designed to treat life-threatening hemorrhage by addressing gaps in current care.
- Reaches non-compressible injury sites via systemic administration
- Achieves hemostasis in 5 minutes after life-threatening injury4
- Overcomes coagulation dysfunction, including that due to use of platelet inhibitors or “lethal triad” conditions 1,3
- Drives faster – but not excess – clotting 1,2,3,4,5
- Efficacy where current treatments demonstrated little-to-no benefit 4
- Data is highly reproducible in predictive models with proven translational power
- Discovery-stage CAY002 is a novel composition designed to address unmet needs for patients with inherited bleeding disorders
- Early pipeline addresses unmet needs across the healing continuum with polyP-based interventions.
Plavix is a registered trademark of Sanofi-Aventis
1.Kudela D, Lu G, Ashford-Hicks AJ, Synthetic Short-Chain Polyphosphate Complexed With Silica Nanoparticle, Corrects Coagulopathy Under Hemodilute, Hypothermic, or Acidotic Conditions as Assessed by In Vitro Coagulation Assays. Mil Med. 2025 Sep 1;190(Supplement_2):297-303.
2.Damien Kudela, Genmin Lu, Lisa Jennings, Kyle Ploense, Andrea Ashford-Hicks. Assessing the pro-hemostatic effect of CAY001 on thrombin generation and thromboelastography. Research and Practice in Thrombosis and Haemostasis – Abstracts from the ISTH 2025 Congress, 2025 Jun; 9(S2): 57.
3.Damien Kudela. A Novel synthetic short-chain polyphosphate (PolyP) complexed with silica nanoparticle (SNP), bypasses cangrelor-induced P2Y12 inhibition and reduces blood loss in a rat tail transection model. JACC. 2025 April 1; Volume 85, Issue 12, Suppl A: 2669.
4.Damien Kudela, PhD, Kyle Ploense, PhD, Genmin Lu, PhD, Charles Pollack, MD, Andrea Ashford-Hicks, James H. Morrissey, PhD3. A Novel Synthetic Short-Chain Polyphosphate (polyP) Complexed with Silica Nanoparticle (SNP) Improves Hemostatic Outcomes in Severe Swine and Rat Injury Models. Blood 144 (2024): 3964-3965.
5.Kudela D, Lu G, Smith SA, Ashford-Hicks AJ, Morrissey JH. A synthetic short-chain polyphosphate (polyP) complexed with silica nanoparticle (SNP), has pro-hemostatic activities as assessed by in vitro and ex vivo studies. Research and Practice in Thrombosis and Haemostasis – Abstracts from the ISTH 2024 Congress, 2024 Aug; 8(S2): 22.