Cofactor that accelerates and/or normalizes thrombin production
- Polyphosphate (PolyP), part of the natural healing response, is stored in platelets
- It is targeted to the site of bleeding and is inert elsewhere in the body
- As a co-factor, it modulates the activation efficiency of key coagulation factors
- This accelerates and / or normalizes thrombin production
- Impaired thrombin production is the hallmark of coagulation dysfunction, including that due to blood thinners, factor deficiency, hemodilution, acidosis and hypothermia (the “lethal triad”)
- By accelerating / normalizing thrombin, PolyP can accelerate / restore the ability to clot
- PolyP enables clot formation; current treatments slow clot breakdown
